The researchers published a paper reporting on this research that can be found here:Ī second paper is in preparation to be published in Translational Stroke Research. They are now planning to secure further funding to test this. Therefore the researchers conclude that MSCs modified by exposure to IL-1 could be a promising treatment for stroke patients. While conventional stroke therapies can at best limit damage to the brain, stem cell therapies work on a different level (angiogenic, neurotrophic, neuro. This suggests MSCs don’t increase the risk of blood clot formation. They were detected in brain vessels, which means MSCs travelled from injection site in the artery to the brain.įinally, blood flow in the brain was not found to be altered and there wasn’t an increased number of clot-forming cells (platelet aggregates).There also wasn’t a significant difference in most markers of inflammation, except a reduction in IL-6 in the lungs.There wasn’t a significant difference, but a trend of more newly generated neurons and cells that line blood vessels.The researchers looked at markers in brain tissue for growth of new neurons (neurogenesis) or blood vessels (angiogenesis), inflammation and distribution of MSCs. They also found that MSCs that had not been exposed to IL-1 reduced brain damage and neurological deficits in the shorter term compared to where the vehicle was injected, but this was not significant. Better recovery indicated by weight assessment, but only at the longer term time point.No difference in nest building behaviour or burrowing test, which are indicators of well-being.A significantly reduced amount of damaged brain tissue and neurological deficits detected.They found that in mice injected with modified MSCs compared to the vehicle, there was: They looked at various markers of stroke recovery in the short term (3 days) and the longer term (14-days) after stroke. The researchers either injected MSCs that had been modified by exposure to IL-1, MSCs that had not been exposed or the injection medium without MSCs (the vehicle) into the artery of mice that had stroke caused by a blood clot. The researchers are now planning to secure funding to test the safety and efficacy of these MSCs in stroke patients. ![]() This treatment method could be used with, and potentially increase the effectiveness of thrombectomy. This research found that injecting modified MSCs into an artery leading to the brain can promote recovery after stroke. Find out more about the Stroke Association See all.Find out more ways to get involved See all.Find out more about the support we offer See all.
0 Comments
Leave a Reply. |